Vitamin B1
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چکیده
Vitamin B1 is a watersoluble vitamin. It consists out of a pyrimidineand a thiazol ring, which are synthesized independently and linked afterwards.Vitamin B1 is de novo produced by many plants and microorganisms. Humans and animals have to take it up by nutrition. They are only able to do the phosphorylation reaction of the thiamin molecule. Thiamin is found free and as mono-, diand triphosphate. The different forms can be transfered into each other. The metabolic active form is thiamin diphosphate in the body and thiamin triphosphate in the brain. Thiamin diphosphate (TDP) works as thermostable coenzyme in many enzymes of the carbohydrate and amino acid metabolism. In most reactions TDP catalyzes the cleavage of C-C bonds. In the nervous system vitamin B1 is needed for the stimulation of nerve cells. The classical disease of patients with a lack of vitamin B1 is Beriberi, which is known from regions where people eating predominantly white rice. The symtoms are paralysis, muscle dystrophia and heart failure. Other diseases are the Wernicke encephalopathy, the Korsakow syndrome and some forms of the Landry`s paralysis. In industrialized countries alcoholism seems to be the most important reason for a lack of vitamin B1. In alcoholics the thiamin resorption is disturbed. Due to a damage of the liver the storage capacity of vitamin B1 is reduced.
منابع مشابه
Action de diverses preparations denommees (vitamin b1) sur les cultures de Leishmania tropica
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